I'm not going to say it went "horribly wrong" but it went pretty wrong nonetheless.

They weren't able to undo the effects or figure out why it went wrong...

But all these types of attempts always do go wrong and never work...

There will never be a fountain of youth etc. because all such things go against the nature of the universe/existence itself.

They do these experiments on the masses...

What we are today is a conglomerate of failed experiments which had a multitude of consequences unforeseen and irreparable.

Nothing has really been learned from the repeated failures because they just keep making attempts.

They'll never stop.

They've been trying to do this in a lot of ways from micro to macro basically forever.

They do it biologically, they do it with food, vaccines, water supplies...

They do it with places, manipulating locations through a variety of methods, including but not limited to frequency technology, flora, fauna...

And it's all gone wrong, with varying degrees of severity.

Many of their failed attempts manifest themselves in certain diseases, viruses, etc.

There's another attempt which has been made during the past 30 years with genetically modified trees.