Endometriosis.

[Mister Obvious]

Antihistamines show potential as an endometriosis treatment because mast cells in endometrial lesions release histamine, a key inflammatory mediator.

By blocking histamine receptors, antihistamines can help reduce inflammation and symptoms like pain, although this approach is not yet a standard, widely-used treatment. Research into H1-antihistamines suggests they could be used alongside established hormonal therapies to manage endometriosis.

Loratadine is being investigated as a potential endometriosis treatment because it can suppress the growth and migration of endometrial cells by inhibiting the TRPV2 channel.

https://pubmed.ncbi.nlm.nih.gov/35714693

'Bout to pop some loratadine.